![]() It is important that quantifications are accurate and represent what is biologically observed. It is frequently difficult to manually quantify the characteristics of skeletal muscle cells in a dependable and error-free manner because their morphology can vary widely depending on differentiation stage. Muscle cell differentiation can be estimated by measuring the fusion index, which is the percentage of nuclei within differentiated myotubes. Skeletal muscle cells go through differentiation where mononucleated myoblasts fuse with each other to form elongated, multinucleated myotubes. For example, a low viability rate after protein depletion may indicate its involvement in cell growth (or apoptosis). Characteristics like cell viability and fusion can be analyzed to determine the role of specific proteins, culturing conditions, or stimuli on the myogenic process. Skeletal muscle cells are easy to culture and thus are often utilized to study different molecular and cellular aspects of myogenesis. Therefore, we propose ViaFuse as a robust and meticulous method to quantify skeletal muscle cell viability and differentiation. Furthermore, ViaFuse is compatible with many computer systems, has a very intuitive interface, and does not require prior complex mathematical knowledge. Additionally, the ViaFuse macros work with Fiji, an existing imaging software widely used by skeletal muscle researchers. The ViaFuse macros require little computer power or space to run and user inputs to the ViaFuse macros are minimal, thereby automating the analysis process in a quick, easy, and accurate fashion. ViaFuse can detect the borders of myotubes and identify nuclear clumps which have been limitations of previous muscle-centric imaging software. We observed a high degree of correlation between all methods of quantification. We compared the values achieved using the ViaFuse macros first with manual quantification performed by researchers and second with those obtained utilizing the MATLAB muscle-centric software MyoCount. To test ViaFuse, we utilized immunofluorescence images of differentiated myotubes where the capping actin protein of muscle z-line subunit beta (CAPZB) was depleted in comparison with control cells. Here, we developed a new Fiji macro package called ViaFuse (that stands for viability and fusion) to measure skeletal muscle cell viability and differentiation. It is unclear from this announcement whether Empiria Studio will support acquisition for Odyssey FC imaging systems previously using Image Studio or if licenses will be granted to owners of machines previously using Image Studio.Measuring biological features of skeletal muscle cells is difficult because of their unique morphology and multinucleate nature upon differentiation. In its place, LICOR has released Empiria Studio, a commercial product. As of 2021, Image Studio Lite has been discontinued and is no longer available for download. Image Studio™ Lite is free image processing software used for quantitation of Western blot images and images from related experiments.dbc:Java_(programming_language)_software.It is unclear from this announcement whether Empiria Studio will support acquisition for Odyssey FC imaging systems previously using Image Studio or if licenses will be granted to owners of machines previously using Image Studio. ![]()
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![]() ![]() The source does not want to be identified in any way, even on condition of anonymity. The information can be used but without attribution. AP reporters should object vigorously when a source wants to brief a group of reporters on background and try to persuade the source to put the briefing on the record.ĭeep background. Generally, the sources do not want their names published but will agree to a description of their position. The information can be published but only under conditions negotiated with the source. The information cannot be used for publication. The information can be used with no caveats, quoting the source by name. Before any interview in which any degree of anonymity is expected, there should be a discussion in which the ground rules are set explicitly. Not everyone understands “off the record” or “on background” to mean the same things. If a reporter other than the bylined staffer contributes anonymous material to a story, that reporter should be given credit as a contributor to the story.Īll complaints and questions about the authenticity or veracity of anonymous material – from inside or outside the AP – must be promptly brought to the news manager's attention. Stories that use anonymous sources must carry a reporter's byline. We should just state the information as fact. And we should not attribute information to anonymous sources when it is obvious or well known. We must not say that a person declined comment when that person the person is already quoted anonymously. We should be as descriptive as possible: "according to top White House aides" or "a senior official in the British Foreign Office." The description of a source must never be altered without consulting the reporter. The story also must provide attribution that establishes the source's credibility simply quoting "a source" is not allowed. If the story hinges on documents, as opposed to interviews, the reporter must describe how the documents were obtained, at least to the extent possible. And, when it’s relevant, we must describe the source's motive for disclosing the information. We must explain in the story why the source requested anonymity. In rare cases, one source will be sufficient – when material comes from an authoritative figure who provides information so detailed that there is no question of its accuracy. Stories should be held while attempts are made to reach additional sources for confirmation or elaboration. The AP routinely seeks and requires more than one source when sourcing is anonymous. At the end of the interview, the reporter should try once again to move onto the record some or all of the information that was given on a background basis. If the source wants to set conditions, these should be negotiated at the start of the interview. Reporters should proceed with interviews on the assumption they are on the record. Only after they are assured that the source material has been vetted by a manager should editors and producers allow it to be used. The manager must know the identity of the source, and is obligated, like the reporter, to keep the source's identity confidential. The manager is responsible for vetting the material and making sure it meets AP guidelines. ![]() Reporters who intend to use material from anonymous sources must get approval from their news manager before sending the story to the desk. The source is reliable, and in a position to have direct knowledge of the information. The information is not available except under the conditions of anonymity imposed by the source.ģ. The material is information and not opinion or speculation, and is vital to the report.Ģ. Under AP's rules, material from anonymous sources may be used only if:ġ. When a newsmaker insists on background or off-the-record ground rules, we must adhere to a strict set of guidelines, enforced by AP news managers. Whenever possible, we pursue information on the record. Transparency is critical to our credibility with the public and our subscribers. ![]() ![]() ![]() The disease causes certain nerve cells in the brain and spinal cord to waste away. Huntington's disease is caused by a genetic change. Studies are ongoing to determine how having mixed dementia affects symptoms and treatments. People with mixed dementia can have Alzheimer's disease, vascular dementia and Lewy body dementia. Autopsy studies of the brains of people age 80 and older who had dementia indicate that many had a combination of several causes. Common symptoms affect behavior, personality, thinking, judgment, language and movement. These areas are associated with personality, behavior and language. This is a group of diseases characterized by the breakdown of nerve cells and their connections in the frontal and temporal lobes of the brain. Other signs include uncoordinated or slow movement, tremors, and stiffness, known as parkinsonism. Symptoms also include problems with focus and attention. Lewy body dementia is one of the more common types of dementia.Ĭommon symptoms include acting out dreams in sleep and seeing things that aren't there, known as visual hallucinations. They have been found in the brains of people with Lewy body dementia, Alzheimer's disease and Parkinson's disease. Lewy bodies are balloonlike clumps of protein. These tend to be more noticeable than memory loss. The most common symptoms of vascular dementia include problems with problem-solving, slowed thinking, and loss of focus and organization. Blood vessel problems can cause stroke or affect the brain in other ways, such as by damaging the fibers in the white matter of the brain. This type of dementia is caused by damage to the vessels that supply blood to the brain. It's thought that these clumps damage healthy brain cells and the fibers connecting them. Tangles are fibrous masses made up of tau protein. Plaques are clumps of a protein called beta-amyloid. People with Alzheimer's disease have plaques and tangles in their brains. While several genes are probably involved in Alzheimer's disease, one important gene that increases risk is apolipoprotein E4 (APOE). These gene changes can be passed down from parent to child. This is the most common cause of dementia.Īlthough not all causes of Alzheimer's disease are known, experts do know that a small percentage are related to changes in three genes. Types of dementias that worsen and aren't reversible include:Īlzheimer's disease. Progressive dementiasĭementias that are progressive get worse over time. When this occurs, dementia symptoms may improve with treatment. ![]() Not getting enough of certain vitamins or minerals also can cause dementia symptoms. And some medicines can cause a reaction that includes dementia symptoms. Also, some diseases have symptoms like those of dementia. They may be grouped by the protein or proteins deposited in the brain or by the part of the brain that's affected. Dementia can affect people differently.ĭementias are often grouped by what they have in common. The symptoms depend on the area of the brain that's damaged. ![]() Dementia is caused by damage to or loss of nerve cells and their connections in the brain. ![]() ![]() ![]() ![]() It is clear and intuitive, divided into a central workspace window, a toolbar on the left side of the screen, an options window at the top, and a small section showing layers and masks on the right side of the screen. Interface: A smooth and carefully organized experienceĭespite having evolved over the years, the interface of Adobe Photoshop CC remains true to its structure, being easily accessible for those familiar with previous versions of the program. From it, it is possible to create designs, interfaces, and applications for any type of webpage in a matter of seconds. Web design- In addition to creating and retouching images, Adobe's software is also an essential tool for web designers.Drawing and illustration- The program includes all the necessary tools and brushes (in addition to being able to create your own) to shape any type of digital illustration from scratch.Creation of graphics and effects- Photoshop is the leading program for creating digital content, becoming the most used tool among professional graphic designers.Manipulation of photographs- As a digital composition tool, Photoshop allows for transforming and modifying elements of a photograph, adding all kinds of unique effects.Image editing, correction, and retouching- Photoshop CC allows for all kinds of basic edits (cropping, color adjustments, brightness, etc.) as well as correcting and retouching images (improving photos, smoothing skin, removing imperfections, etc.).Known as the industry's reference program, Photoshop is the most downloaded and used program when it comes to creating digital content. It is used in a wide variety of fields, becoming the standard software for graphic design, photo editing, and digital illustration. Photoshop is a well-known image and photo editing program developed by Adobe. Would you like to know why? What is Adobe Photoshop and what is it used for? Despite having a quite steep learning curve, Photoshop is presented as the industry standard compared to alternatives such as GIMP, Krita, CorelDraw, or the more recent Procreate. Developed by Adobe and integrated within the Creative Cloud suite, Photoshop is a powerful tool to enhance, edit, and manipulate any image with amazing results. ![]() Dinkar Kamat Updated 10 days ago The market-leading image and photo editorĪdobe Photoshop CC is the image editing software market reference, becoming an essential tool for professionals and enthusiasts in the world of digital photography. ![]() ![]() ![]() And the “Periodic Table” option highlights each element, and you move the cursor over the table. For example, if you set the “Fluids” option, the desktop will react to the system volume and cursor. Also, depending on the animation, you may get some interactions. (Optional) Click the Customize option from the context menu to adjust the settings depending on the wallpaper features.Īfter you complete the steps, the live wallpaper will apply to the desktop. To set a live wallpaper as a background on the Windows 11 desktop, use these steps:Ĭlick the menu (three-dotted) button and select the “Set as Wallpaper” option. Once you complete the steps, you can use the app to set living wallpapers on your desktop. Open Lively Wallpaper app on the Microsoft Store. To install the Lively Wallpaper app, use these steps: If you want to set live wallpapers on Windows 11, you must install the app and select the animation. This guide will teach you how to set animated wallpapers on Windows 11. The application offers a library with many live wallpapers you can choose from to set as background on Windows 11, but you can always add custom ones. Lively Wallpaper is an open-source application that allows you to set videos, webpages, and GIF images as desktop wallpapers and screensavers. You can use a live background on Windows 11 similar to those animated wallpapers on Android with the “Lively Wallpaper” app available through the Microsoft Store. UPDATED : On Windows 11, you can set live wallpapers on the desktop, but not officially. ![]() To set live wallpapers on Windows 11, install “Lively Wallpaper,” open the app, click on “Library,” right-click the live wallpaper, and choose “Set as Wallpaper.”. ![]() ![]() ![]()
![]() ![]() Positioned at least half a metre away from objects such as TVs, wireless speakers, cordless phones and radiators (keep the Hub cool). But if you’re getting broadband speed test results that are close to our estimated speeds for your package and you’re finding that the connection is too slow, it may be time to upgrade your broadband to a faster speed. You can also follow our guide on how to improve latency. These tips and tricks can help improve connection and combat slower speeds. Test your broadband speed at different times of day for an average reading.Check your device is not too old to be compatible with high broadband speeds.Switch off antivirus software and firewalls, if possible.Disconnect your other devices or consoles from the WiFi as they can interfere with the signal. ![]() Close all other browser tabs, windows and apps.Ways to make your internet speed check more accurate But using an Ethernet cable to connect your device to the Hub will give you the most accurate broadband speed test results and a faster connection than wireless broadband. Obviously, you can run a WiFi test to check what speeds you’re getting around your home. And if your results vary, don’t worry that’s normal, due to factors such as the time of day and number of devices sharing your broadband when you repeat the internet speed test. If anything, it’s more likely to underestimate speeds – it’s a strict, Ofcom-approved test (other speed checkers may not be). Our broadband speed test is generally pretty accurate and the results are a good reflection of the speeds you were getting during the test. ![]() ![]() ![]() On downloading, you’ll get the two font styles in TTF format. The font comes in two styles, Regular and Alts Regular, the latter contains a bunch of alternate characters. It features graceful flowing letterforms with curly swashes. Calligraffitti is also available on Google Fonts.ĭesigned by Apostrophic Labs, Freebooter Script is a cursive font ideal for adding a formal feel to your design. You can download it in TTF format and use in commercial work for free. It features unconnected characters and has high legibility that makes it suitable for use in text as well as headlines. Font Format: TTF.Ĭalligraffitti by Open Window is based on the calligraphic lettering of the designer’s mother. Senzana, it includes uppercase and lowercase characters, numbers and glyphs. The font is free for commercial use and is available in OTF and TTF formats. This flowing script is perfect for designing wedding invitations, letterheads, logos, and T-shirt quotes.Ĭhristopher is an oblique calligraphic style font designed for branding, calligraphic projects, apparel designs, posters and packaging. It comes with full set of lowercase and uppercase letters, numerals and punctuations. Salmela is a hand lettering calligraphy typeface from Genesislab. View Alex Brush font specimen on Google Fonts. Designed by TypeSETit, the font is available for free download in TTF format. Its short ascenders and descenders allow Alex Brush to have a great legibility. Lauren is available for free download in OTF, TTF and Web Fonts (WOFF & WOFF2) formats.Īlex Brush is an elegant brush font with swash caps and a contemporary hand-lettered feel. It includes rich stylistic alternates and ligatures that you can use to create impressive designs for greeting cards, branding materials, quotes, posters, and much more. Lauren is a beautiful handmade calligraphy font designed by Dimitriy Chirkov. ![]() It comes in two weights – Regular and Bold and can be downloaded in TTF format. Tangerine is also available on Google Web Fonts. Tall ascenders and short heights of lower case letters are the most distinct characteristics of this typeface created by Japanese type designer Toshi Omagari. Tangerine is a free calligraphic typeface inspired by Italic chancery calligraphy styles from the 16th and 17th centuries. It includes many contextual and stylistic alternates, initial and terminal contextual swashes, ligatures and also supports international characters. Nolean Script can be downloaded in OTF format and is free for both personal and commercial use. Noelan Script is a lovely modern calligraphy font with a clean design from Ndroadv. The font comes with free personal and commercial use license. Featuring 351 glyphs, it is available for free download from Font Bundles in OTF format. Olivia Script is a stylish and elegant calligraphic typeface suited for multiple purposes such as wedding invitations, greeting cards, posters and more. ![]() We have included the links to Google Web Fonts directory wherever applicable. You can pair them with contrasting serifs and sans serifs for a balanced typography layout.Īll the fonts showcased below are free for personal and/or commercial use. Available for download in TTF or OTF format, these fonts are compatible with both macOS and Windows. Fonts like Tangerine and Calligraffitti are also available on Google Fonts from where you can serve them on your websites. These fonts come in a range of styles, from fonts with dreamy flourishes to fonts that mimic the penmanship of another era to modern calligraphy typefaces.Ĭalligraphy scripts are perfect for when you need to add a touch of elegance and a handcrafted feel to your work especially in wedding stationery, event invitations, branding and packaging. Some of the fonts on this list such as Noelan and Lauren include additional ligatures and alternate glyphs that you can use to create a unique design. In this post, we showcase some of the most beautiful calligraphy fonts that are available for free download. ![]() Calligraphy fonts bring the charm of traditional calligraphy writing to digital typography. ![]() ![]() ![]() ![]() ![]() Peruse the list for yourself, let the kids weigh in, and then get ready to curl up on the sofa and queue up the best kids movies on Netflix. There, he meets Willy, a young Orca whale who, just like Jesse, has been separated from his family. When a mischievous orphan named Jesse vandalizes a theme park, he’s placed with foster parents and assigned to work at the park to make amends. 01 Double Jeopardy (1999) In this exciting thriller, a wife is framed for the murder of her husband and faces time in jail. Chakravarthy), who moves to the city in hopes of making it big. Free Willy (1993) Rated: PG Where to Watch: Rent on Amazon Prime Video. It narrates the tale of the titular character (played by J. So instead of watching the same movie for the umpteenth time, help your kids find a new favorite. Satya (1998) The first of Ram Gopal Varmas gangster films saga and one of the most underrated releases of the ‘90s, Satya provides an unfiltered dive into Mumbai’s underworld. But, if inspiration isn't striking or you're in a crunch to get a movie in before bedtime, we've got 25 great kids' movies that are on Netflix to choose from.įrom animated favorites like The Croods to book adaptations like The Lorax to Netflix Originals that are actually good like Yes Day, there's something for everyone and then some (even some that parents will equally enjoy). Plus, you can even set up kids' mode, so they can browse for themselves. John Goodman, Elizabeth Perkins, Rick Moranis, Rosie ODonnell, Kyle MacLachlan, Halle Berry. When the children invite their friends round for a. Willy Wonka & The Chocolate Factory (1971) We’ve crowned 1971’s Willy Wonka & The Chocolate Factory as the best Roald Dahl movie ever made. Though Netflix may not have as many kids' movies to choose from as Disney Plus, they still have a great selection of Netflix originals and blockbuster movies made just for kids. The Finch family are your average American household parents with normal jobs, two kids and a dog or so it seems. With so many streaming services out today, and even more kids' movies to sift through, it can be hard to find a movie all the kids will love that you haven't already seen a million times ( Frozen we're looking at you.). ![]() ![]() ![]() Kind of feel I’m trying to advertise these.I’m not… To upgrade my Stereo $900-$1,500 plus $500+ for install…but for $200.00 I get everything to upgrade for all the reasons I wanted to upgrade.Īmazon sells them for a bit more but bought mine off of there website for cheaper, used promo VET30 got mine for all about $200.00. Making calls is easier, than before… its not SYNC 2or3, there might be better system head units. Maybe its just the Novelty of New but having this is and figuring it all out has been kind of Fun. ![]() Was even able to personalize the start up screen. I just keep my iPhone in my pocket mostly now. Split the cable sheathing a bit more then hooked up ground, used provided cable & fuse to hook it up to fusebox… #13. Bought the hard line power cable for $10.00, I bought the camera to set up in the front. There are 4-5 different models 7”, 9” & 10.3” narrow screen, one with larger speakers… in black & silver I also got it as a test run, if it works out I’ll use this or get one for my Daughters car. Otherwise hooks up to iPhone or Android via. Mine…Power Cable to fusebox #13, Bluetooth & 3.5mm cable " THIS LINK IS FOR A 2009-2014 F-150 THERE ARE OTHERS AVAILABLE " it was just that I felt it looked better a little lower. I purchased & planned to use a BuiltRight dash mount. I'm still able to Sirius XM, Radio, CD's, Sony Hard drive, Navigation. Having a lot of fun with this, bought some 4gb & 8gb usb & TF disks for $5-$6 and commenced to Loaded Movies, Music & Pictures Shuffle pictures, watch Movies (not while driving of course.but I could) Mirror my iPhone, Stream off of iPhone (Android if I had that). I can bluetooth Apple CarPlay, iTunes playlist, using USB or TF Disk. Drilled a 3/8 hole, routed audio cable to existing radio jack & power cable to fuse box (used fuse 13) both through glove box. Traced mini shelf pad and duplicated a piece of Metal, painted and 3M tape mounted bracket then screwed it down with existing hardware. The longest part was trying decide where to mount it. Of course I wanted to hide the cables and look as close to a stock configuration as possible. ![]() So I purchased a Carpuride 9" for $200 quite possibly the easiest install ever. But with SYNC 1 there is no easy DownLoad to use Apple CarPlay. My 2010 Harley-Davidson Edition has the Sony Navigation. I don't have to try and figure out how to set up the Navigation. Just wish it was easier to update.Īfter a lot of travel and car rentals I've gotten used to Apple Car Play, get in an go. I've been somewhat happy with my Stock Stereo. ![]() |
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